My Brother has been using a 300 Weatherby for about 25 years on Moose and Grizzlies. Hasn't let him down yet. 200gr Noslers are his 1st choice, but he's killed just as many or more with 180's.
+1 on the .300Weatherby! 200gr AB's--84gr of H-1000 at 3,000fps gets their attention right away.
G