Plusses:
I like my 6.5x55s with 140gr bullets for deer hunting. It shoots plenty flat and penetrates very well. When I place one of these slugs on the shoulder of a deer standing broadside, the deer falls down at the shot and dies instantly. I don't load hot. My manuals say my bullets are trvelling about 2600 fps. Inexpensive bullets behave well at this velocity, so I practice and hunt with the same load. Recoil is lighter than any caliber on the '06 case or larger. I like it.
Minuses:
...I'm thinking...
OK, larger bullets make larger holes, and animals shot through the ribcage with larger calibers bleed more profusely and may die a bit quicker. This matters to people that aim behind the shoulders.