I had a remington varmit rifle in 22-250 26 inch heavy that shot
many groundhogs at 300to500 yds I used 41 gr of varget and
a 35gr NTX hornady with a cci br#2 vol across the croney was 4448fps never had a exit wound stoped them cold but I would have to say is my 6mm-06 with a 1in12 twist 55gr combined tech over
55gr varget will stop anything varmit class vol 4200 also with
br#2 primer

It is better to have it and not need it , than to
need it and not have it ( by master gunsmith & very wise friend )