Nothing at all wrong with a 22-250. It's done it all, but the 204 Ruger will do it as well, less muzzle jump.
For varmints....it gets my nod.
For predators(saving hides)a 17 Rem (or maybe 17-204 *grin*).
Working on one just like my 204 below but put together in a 17 Cal. (cant just buy one in 17)
I have had both, now want both in the same rifle.
Just my 2 cents and dont mean I WONT buy another 22-250. Still love em, but wont be because I "need" one with these two. Just another fun gun.
In fact I just realized Id trade for a CZ 550 in 22-250 for my second NIB 204 in classifieds. WHY didnt I think of that? lol
God Bless