For plinking, practice, and generally light stuff, I use 6.0gr of Red Dot under a 200gr cast RNFP.

For deer hunting and higher throttle stuff, I run 24.0gr of 2400 under a 210gr Gold Dot.

For big stuff and playing with my buddies, I use 18.5gr of 2400 under a 310gr cast FPGC.

That pretty much covers the full spectrum for me.