The easiest way I found to operate the safety knob is with the heel of the thumb - push and twist. Its not a problem without a scope in the way. I don't know how to do it with a scope. I've seen it done with a thumbtip and could do it back in the day, but these days with arthritis that much pressure on my thumb would put me into orbit. I went there yesterday with injections in my heel for plantar fasciitis - OMGosh did that friggin hurt!