Are you talking hunting them or defense?

I'd say for hunting, a scoped 338 win mag or 375 H&H is good. Hunting can call for longer shots, or precise shots in thick cover and poor lighting. I don't see the quick follow up shots of a lever gun as a fair trade for the most important precise first shot that I'd want to deliver from a scoped accurate bolt gun. I'd also venture to say that the terminal performance of a best quality expanding bullet from a 338 or 375 would be better than a 444.