I hunted with one load and one bullet for about twenty years, a 165-grain Nosler Partition in a .30-06. I reloaded all of my ammo and shot one bull elk, a lot of whitetails and pronghorns, a few mule deer and the occasional feral hog. When my daughters wanted to start hunting, I bought a .243 and then a couple of 7mm-08s, a .270 for myself (followed eventually by four more) and a few other rifles.
For the kids' and grand kids' rifles, I work up one load that will work well in their individual rifles for anything that they will have a chance to hunt and we stick with it. However, I like to experiment with different cartridges and different rifles and different bullets and different powders. It's what I do instead of woodworking, playing golf, gardening and any number of other past-time pursuits that engage other people. I recognize that I am an indifferent amateur gunsmith, but I like to fool around with all of this in the evening while my wife watches NCIS and plays spider solitaire on her laptop computer.