Yes, I have, actually. I bought a Ruger M77 African in 375 Ruger 2 years ago. I've killed a bison cow only with it so far... it shoots well for me. It has punch a lot of holes in paper besides that bison.
Dunno yet what I'll take for my "light" rifle, if I take one. The 375 might do for everything, as all I really want is my buff, a kudu, and an eland... anything else will be gravy, so to speak. If I take a second rifle it will likely be a 30-06 Model 70, or perhaps my BLR in 358 Win.
I have been on two plains games hunts and as best as I can remember the only thing I didn't use a 375 H&H for was Springbok.
I am hoping to get back for my 60th for Cape Buffalo. I will have the air miles now I just need the cash.
