I did a one rifle safari with my 416 Rigby and it worked very well.
Regarding the 270gr TSX, you may want to check with your PH first. I was hunting buffalo herds and my PH specifically did not want the TSX because of the potential of passing through and wounding another animal. I used A-Frames and they worked fine.
I suggest whatever rifle you take, bring some solids if there is any chance at all of taking the tiny 10. I shot my suni with a 400gr Barnes banded solid and it left a 40 cal hole in and out. On the next safari I forgot solids and shot a klipspringer with a 225gr partition from of a 338WM and the off side evaporated.
