I have shot one cape buffalo using a 375 H&H with 300 grain Barnes TSX bullets backed up by Hornady 300 grain DGS. While my experience is limited, I think it is a great combo and I would happily use it again, except I would probably load more softs into the rifle, maybe 3 softs then 2 solids instead of 1 soft and 4 solids (I have a CZ, it holds 5+1). Reason I would change that is the solids didn't seem to have as traumatic of an effect on the buffalo as the soft did. The first shot with the TSX knocked him over and he did not regain his footing, but I put four more solids into him to finish him off. I feel that less soft points would have been needed to achieve the same result.
The 375 was the only rifle I brought as well. If there is a camp rifle, you can always use that in the event of a failure of your rifle.
