My son and I both shot deer this past year with his new Ruger American rifle in 22-250 with a 1-10 twist.
I loaded up a few dozen rounds of Barnes 53gr tsx bullets to about 3300fps (pretty mild) and they worked just dandy.
I am going to try and see if it will stabilize the tsx 62gr this summer.

**********************
[the member formerly known as fluffy}