WE've kept the 63s in a couple of 175ish pound bucks, by neck shots, I don't do neck, but my BIL does. Think he has 3 so far that were stopped by the neck bone.
Thats why I shoot mono... rather trail a dead deer, than wonder if the bullet never made it to vitals.
Especially with the 22-250s added speed.
When I barrel up my 788 to 22/6mm I"ll certainly run TSX for sure.