I have taken quite a few deer with the 22-250 and FWIW i think the non premium bullets kill quicker (not deader) than the premiums, especially mono metal bullets. I used the tsx for a while and though I never lost a deer I did have more run than with cup and core bullets.
The bullet I have had the most luck with as far as terminal performance and sheer accuracy is hands down the 63 grain sierra smp. I have yet to keep one in a deer and they shoot lights out in every rifle I have tried them in. They also work for you 1 in 14" twist guys out there too
