From my limited personal experience, I would not use .22 mag Vmax's on coyotes. Tried that a couple of years ago. Made what I thought was a decent hit on a coyote at about 30 yds. Trailed him about 150 yds in the snow to a rocky outcropping where he holed up. He left a blood trail, but I think the bullet blew up without penetrating. I've not had any problem with 40 gr Vmax's in .22 centerfires.
