Good friend in a wheelchair used a 243 77V w/a 2.5x10 for years and it was always set @ "2&10" (200 yds on the focus and 10X). I have no idea how many animals ( G.Squirrels-Elk) were killed with it but a lot more than holes in paper before the barrel gave up. He used 85gr HPBT Sierra's and Mil surp. H-414. Muddy