I load the 140 XPB's for a field carry load to a measly 1400 fps in an old first gen Colt Trooper with a 4" barrel, that load penetrates to the high heavens in homemade test media, complete with random cow bones in the box to boot, god knows the speeds you could push that bullet too with a top end charge of H-110/296 in a 10" barrel, even if you pin the ears all the way back you'll have an expanded solid of at least 45 cal punching on through, the damage incurred to the critter by getting the petals all laid back against the bullets shank would have to be massive.
Put it in the right spot and you will eat.