I have a 458 Socom, 6.8 SPC, and a 300 Ham'r that I have intended to hunt deer with, but never have.
I have a 300 grain HP and a 405 grain LBT load ready to go for the .458, and I intend to try the 300 TTSX on test medium. I've got a ready-to-go load with the 120 grain SST for the 6.8, and if they ever become available, I'd like to try the 110 grain Accubond. The 300 Ham'r has three loads ready to go, a 130 grain RN, 135 grain FTX, and a 150 grain Speer spitzer. I want to try the 150 grain Hornady RN in this cartridge, and I have a couple of others that are probably too light/frangible for deer, but coyotes would be in the realm of their capability.
I've shot groundhogs with 5.56/50 grain Blitzkings.
I wouldn't be afraid to try big black bear at all with the .458 Socom.