I have 2, a cut-down rifle and a carbine, both in 308. I have had them in 243 and 284 too. The 243s and 308s have all worked for me, but I never could get any of the 284s to function as well, as they were hyper sensitive about feeding reliably from different magazines. I have used the cut-down 308 for culling does and inferior bucks with great success.
There was a recall on the firing pin that you can look up on the web, if you have the SN of the rifle. Other than that, the only trouble that I have had with a Winchester 100 was a used 243 that had a burr on the edge of the chamber that would break the extractor when the action cycled. The burr was probably caused by some previous owner prying a stuck case out of the chamber with a screwdriver blade, but it was an easy fix and the rifle functioned fine when it was fixed.
There are a lot of people who don't like the Winchester 100, but most of them have never owned 1, they are basing their opinion of the bad experience of others. Since they have a poor reputation, Winchester 100s in good condition can often be bought for $250 +/-. I paid $150 for the 308 carbine and it came with a couple extra magazines, plus a Weaver V4.5 in Weaver mounts.
Jeff