Way too many variables to even start to debate....my exp has been that 30/06 and 7 mm08 and 257 Roberts kill about the same given the same distance. 243 not so good. Lots of tracking and blood shot meat...but then again I shot a few with 220 swift it was like a lightning bolt....po ackley wrote about this in his books, testing on feral donkeys..he liked the high vol...