I have put 100 grain 25 cal partition threw couple feet of deer spine, destroyed both shoulder blades and spine between between them and exit, 'via 257 rob and a 25-06' To break that much bone on deer and still exit I have no hesitation for use on elk. Things could only get better with the heavier partitions in 25 cal rifles
I DO take my 25 cal rifles on elk hunts, no qualms. But like other rifle loons, I have other calibers to use also... I just have not found an elk to run a 25 cal bullet into yet.
Elk and moose are a little thicker on everything bone, hide, muscle. With 25 cal 100 gr partition, one may not get complete penetration, But I know without a doubt the shot will be precisely and leathally placed do to the easy shoot-ability of rifles chambered in that caliber.
Tanner summed it up best, shot placement first. The rest kinda falls into place.