No real downside at all & tons of upside, especially if you reload; it's a great round.

I've had 4 or them & they effective beyond what you might think on game...........just think of it as a big 270/3006 as trajectories are similar.

I pretty much have used 200/210 or 250 grain bullets exclusively & mostly Nosler Partitions........never seen much reason to mess with the 225's; if I don't feel comfortable with the 210, then the 250 is next up for me.

The Barnes TSX/TTSX are worth a look too, just hasn't been a priority for me yet, but they should be as good in this caliber as they are in others.

4350 is probably the most recommended powder but I've always gotten better performance with RL-19 for lighter bullets & RL-22 for the heavier bullets; all with Fed 215 primers.

MM