I've been shooting 270, 7mm, 3006, 300 mag, 338 win, 375 h&h, 416 rigby, 458's. I don't have any experience hunting anything but deer with these calibers. I've reloaded for all and have come back to the 338 win mag. Think of it as a scaled up 30-06. It has the same trajectory as 30-06, if you can handle the recoil of a 300 mag, the 338 will be no problem. There is a good bullet selection. The deer I took dropped in place with this caliber. The deer I shot with 375 h&h ran 50 yards.
The nice thing about the 338 is it can reach out there better than the 375, has the power for every north American game animal at close range or long range. The recoil is manageable, and it launches heavier bullets for better penetration and less meat damage.
Plus if you ever get curious about the big bores, it will give you an excuse to skip over 375 and go to a 416(great caliber)
The truth is, anything 270 to 458 Lott will have the same effect on deer size game but my understanding is that the 338 will shine on the bigger animals. Like I said, after messing around with so many different calibers, I just have a sweet spot for the 338 win mag.

If you've never tried anything bigger than 30 cal, I'd defiantly say try it out. You may find the bigger bores addicting once you try them

Last edited by Gohip2000; 12/09/15.