I own three P-64-70 Fwts in .270, two Brno21Hs in .280, one HVA-Kreiger in .280 and one Kimber MA 84L in .280AI, prefer 150NPs-.270, and 160NPs in all four .280s.

Cannot tell ANY difference in effect on any BC animals and there are NO "better" rounds with good bullets for BC hunting, but, I do like a CRF .338WM-250NP for solo hunting in Grizzly country.

It is best to have several of both and a few .338s, too.