I watched a guy clean a deer yesterday he shot with a 25-06 Rem coreLkt 100 gn. He shot it quartering to in the shoulder. The shoulder was bloodshot jello.
I would use a better bullet. I want meat, not a pile of useless waste.
Rockchuck nailed it; this anecdote isn't the fault of the cartridge but the bullet.
One could get the same results from a .243/95, .270/130, .280/140, or .30-06/150.
I have a .257AI which is pretty similar to the 25-06 and use 90 gr GMXs with great results. I am sure that 100 gr TTSXs would deliver the goods also.
25-06 is nearly the perfect deer/antelope cartridge IMHO.