I dusted off my 25.06 this last deer season and shot a deer with it last Saturday. It dropped quicker than anything I have used/seen on game! I'm running a 115 Ballistic Tip with 51.0 grain of Reloader 22 and it puts game on the ground, did I mention quickly! I have yet to used factory ammo but positive it will work. Little recoil, if you can call it "recoil" and just plain kills well. That is not a deer I wouldn't use it on. I also have shot a few pigs with it and has the same effect.