I've had a bunch of different scopes on my .375's, up to 3-9x and down to 2.5x. Right now I have a 3x20 Leupold Big Bore, the new version of the original 3x, which is actually about a 3-1/2x.
Have never had any difficulty killing African animals down to bushbuck size with scopes in the 3x range out to 250-300 yards. However, the lone 3-9x I used fell apart quickly, and it was NOT a cheap scope, but a pretty expensive Euro-scope, one of many examples of why I tend to pick fixed-power scopes for rifles with more than average recoil.
