Of course it will work, game cullers use it on Eland and even the 243 but as others have said not my first choice. A premium or Mono 160 probably would not make it through the shoulder joint, but I haven't and wouldn't try it. Trophy fees for Eland are high. A wounded Eland can go miles at a walk that you would have to be jogging to keep up with. To me Eland are an excellent reason to use a medium bore on a plains game hunt. The 7mm mag with a premium 175 is where I start and the 375 is where I end but bigger would not hurt either. The various British 33 & 35s were designed with Eland in mind.

"When you disarm the people, you commence to offend them and show that you distrust them either through cowardice or lack of confidence, and both of these opinions generate hatred." Niccolo Machiavelli