I shot an eland with a .375 H&H using a 300 grain TSX (used the same load for everything to keep it simple). The eland went down pretty quickly. I like the 6.5 CM for a lot of medium game hunting but I think an eland might be stretching it. No doubt a 6.5 could work fine if everything goes right, but there's not much margin for error. Personally, I would probably opt for at least a .30 caliber. But that's just me.