the 416 is a big step up from the 375 (on both ends). if you can handle it, yes it is better.
it's also easy to load for. you'll have to suck it up and buy Norma brass at gold prices and you'll go through a pound of powder per sitting but dies are readily available and it's straightforward.
it can also be loaded from 375 H&H recoil to 416 Wby recoil so you have a lot of leeway there too.
