I have never tried anything smaller than 210 Nosler Partition bullets in my .338 rifles! It is a medium bore and gets 2900-fps using them. In my book that is fast enough and goo for any mule deer etc. I just can't see the sense of going lighter for the sake of velocity.
I can shoot my .300 Win mag or .300 Ultra mag with 180 grain bullets at a velocity of 3130fps to 3350fps respectively in my rifles. I like heavier bullets for medium bore rifles simply put. I have 2 loads for the .338mag.......210 weight and 275 weight in Swift A Frames.
