I killed my first deer in 1949 with a .257 Rbts [desert mule deeer] 2010 whitetail with a .308 In the intervening decades I've killed more than some ungulates on a couple of continents with more than fifteen different cartridges. My experience is if you shoot'em in the chest they all work well, if you shoot'em in the butt, not so much.

Lions is bad. Lions is feerse. Lions ete folks.
Edison Marshall "The Heart of the Hunter"