Apparently, the latitude at which a cartridge is used has more to do with it's effectiveness than bore size, case capacity, or any other ballistic detail. That's the only explanation I can think of for why Alaskan's are able to kill large bear, moose and caribou with 223s and 243s, but as you go south in the lower 48, bigger and bigger cartridges are needed for 100 pound whitetail deer.
Fred: Bergman's Rule in reverse? As applied to rifle cartridges?....that's pretty funny!