I have used the 350 Rem Mag for a long time and prefer the 225 Nosler partition over all other bullets. The extra 200fps over the 250 grain bullet helps with long range expansion and the penetration is still very good. I move up to the 250 with the 358 Norma.

Here is an article I wrote some time ago. It might help.

http://35cal.com/35bullet_study/35bullet_study1.html