A Ruger M77 has always prefered the Speer 250 gr with 58 grains of IMR 4320. Never shot deer with it, only Moose, Elk and Black bear. Tried the 225 grain Nosler Partition in this rifle back in 1990 with three or four different powders, but accuracy was lackluster. Was impressed with the velocity though it was up around 2700 fps.
