Best mileage my '07 4.7 4wd has seen is 20.1 for a 1000 mile round trip to Bend, Or.
Overall I average around 18.5 on the road; 15 in town. I love the Tundra series but wish Toyota had really tried to squeeze the mpgs out of them, shame.
I've had four Tundras and as many T100s.

Granted it was smaller and a v6, but at least the T100 4wd ext cab would deliver a solid 21mpg on the road.