Jordan, I agree with you about the higher BC extending that range a bit. It's just that for me, there isn't really a range or set of conditions where I draw a line in the sand. That line is constantly changing due to wind speed and fluctuations, as well as what terrain that wind is crossing, time of day for tracking, proximity to nasty cover or cliffs if wounded, stability of my shooting position, how worn out I feel, a gut feeling about the shot, and probably some other things I can't think of right now.

I'd like to think I err on the side of safety if one of those borderline shots presents itself, but it depends. I do know that I've never felt handicapped if I was packing a rifle that fired a reasonable game bullet at reasonable velocity.