I'm down to my 500 jefferey which is still a project rifle, one of these days...

If I was to get serious about dangerous game hunting I'd go with a 416 remington. As much as I enjoyed my two 458 lotts, there is just a recoil threshold with 500 gr bullets at 2100+ fps where you simply can't ignore the recoil and it takes significant concentration before squeezing off shots. For a hunting rifle I want something I can get into any field position and ignore recoil, and that is what the 416 offers that the 458 and larger rifles don't.