Currently, a Shiloh 1874 Saddle Rifle - 45/70 with 26" barrel.
Over the years, I've had a total of 4 Marlin 1859SS's, 1 T/C Contender, A Browning 1885, and a C. Sharps 1875..................all in .45/70.
Granted, the .45-70 isn't the best choice for a big bore rifle for dangerous game, but it does get the job done if used in its range.