I would not use Lil'Gun. Way too hot burning. I mean HEAT as in fire, not pressure.
My revolvers all get 296, 2400 is good.
I don't like 4227's as they were very sensitive to gun heat in the .44 but I don't know about the .45. 4227 is super in the .357 max though. Worth a try.
300 MP has not panned out, slower then H110/296 so not enough can be loaded and you should not down load it. Do NOT down load H110 or 296 either.
There is no true sub for H110/296.
Years ago I found a difference in accuracy between H110 and 296. SBH, S&W 29 and many others preferred 296 but the RH loved H110. WW got one batch while Hodgdon got another and I do not know if it is still the same today since Hodgdon has both under their control but I still stay with 296.
