Elmer Keith used 2400 in the 44 magnum. I do too and also have 4 pounds of H110 stashed BUT it is temp sensitive and requires magnum primers here in WYO winters.

4227 is also fine as are Red Dot, Unique and Green dot for light loads. A 300 gr hardcast at 900 fps will kill anything that walks in the lower 48.

My lettered 1926 New Service 45 Colt match with 300 gr plain base sorta Keith design bullet loafs out @800 fps. Using the Keith back position (old eyes), bouncing around Kitty Litter jugs at 100 yds is an 80% game. Valuable revolver so I never stress it.

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