You take cartridges like the Casull,.460 and .500 that burn a lot of slow burning powders at high pressures, pushed by Rifle primers across the cylinder gap of a revolver where the partially burned powder is mixed with oxygen. It is a tough situation for a revolver design. Look back at the problems Ruger had with the .357 Maximum in the Blackhawks. This was before the introduction of Lil'gun.
