Yep. I've used 500gn hard cast lead projectiles at 1,600fp on pigs. Unless they hit bone, the projectile will exit, but it still does a number on them. Feels like I'm firing a 308.
I have another load with a 405gn hard cast lead projectile using Trailboss at 1,000fps ie sub-sonic. I haven't tried it on pigs yet. I have used it on rabbits though because it's quiet and accurate and it was the only rifle I had with me at the time.
I haven't gotten around to using reduced loads with jacketed projectiles yet. Standard loads with 400gn jacketed projectiles are somewhat excessive for pigs.