I have taken my .458 to Africa with good results. The opinion that you can't get decent velocities without excessive powder compression is simply an old wife's tale. It's no trick to get 2200 fps with a 500 grain bullet and a 22" barrel. The Lott only gets 70 fps more at the same pressures.
As for versatility, you can load 350 grain Barnes bullets to 2700 fps with no pressure signs at all. That's like a 30-06 on steroids. According to the computer, it hits with 3000 foot pounds at 300 yards. I'd like to take an elk or a bear with that load.
Unfortunately, the 500 and 350 grain loads will not group to the same elevation at 100 yards unless you lower the 350 grain muzzle velocity to about 2350 fps, which means you don't want to take both on the same hunt.
