I've experienced two different loads having the same POI at 100 yards while testing. Has anyone carried two different loads in your rifle on the same hunt?

For example, if I were to find an elk up close have a 150TTSX in the tube ready to go - but if I came out of the woodline and found an elk 500 yards out, take the TTSX out and have a 162AMAX next in line.

Wouldn't have to worry about construction, penetration or retention up close, but could easily switch - given plenty of time - to something that slips through the air better and at range don't need to worry about it flying apart, like at close range.

Anyone ever try it? See anything wrong with it other than not paying attention to which one you have in the tube?