I found theres really no reason to exceed the power I get from the 10" S&W with the 44 mag load I mentioned using a Lee 310 grain bullet over 21 grains of H110.
it frequently exits deer and hogs from most angles and it has been just as effective pushed at about 1300fps from the 44 mag as 250 fps faster from a hotter handload in my larger 445 DWSM

YES THE ALLOY its cast from matters, use 95% WW and 5% pure tin this results in a bullet that expands slowly but exits and won,t fragment, and while I'm sure to hear a few different opinions Ive used the same ammo in my marlin 1894 carbine with equally good results
http://www.midsouthshooterssupply.com/item/0000690227/6-Cavity-Mold-C430-310-RF-