Most of my deer hunting is with revolvers and you can't beat a SBH Hunter with an Ultra Dot. .44 mag is as good as it gets. Stay away from quick expanding bullets or you won't get two holes. 300 XTP is good. 240's might not exit and you will not have a blood trail. They kill good but you must be able to watch the deer. I figure my revolver kills at over 168 and the .44 has done many of them.