I shot a good sized cow at about 100 yards last year with a 150gr TTSX out of an -06 (Barnes factory loading), advertised at just shy of 3k MV. Slight quartering away shot, complete pass through. Took out the back shoulder on it's way out. She went about 40 yards and death rolled down the hillside.
This would certainly be my choice if I were to use a 150 grain bullet from a 30 caliber rifle on elk.
