Me and my dad have had a LOT of weatherby rifles, I think right now he still has a dozen or so MKVs. He always said that they are pretty unimpressive in standard calibers which I sort of agree with (if im getting a 308 or a 30-06, theres probably better choices).

The ones he has, including a brand new ultra light weight are all in weatherby calibers 240, 357, 300, 340, 378, 338-378. ANd they are all very accurate rifles. He has since sold all the standard caliber ones for one reason or another.