I've used a 300 Win Mag with 200gr. A-Frames, a .375 with 300gr. TSXs, a .270 with 150gr. SPs (camp gun), and a 7x57 with 175gr. Partitions. All worked fine with the exception of the .270 on a black wildebeest which failed to penetrate due to the cup & core bullets-- got the job done but it took a couple of shots.

Next time I'll either take my .300 H&H with 200gr. Partitions and/or my 6.5x54 M-S with 156gr. Oryxs.

Just like any game animal, put a good bullet through the heart/lungs of a kudu/gemsbox/impala/warthog and it will die.